A bit of historical context

Kulldorf's tweet is a little less surprising if you know a bit about his recent activities and affiliations. We could make this a discussion about the heavily subsidized anti-vax adjacent libertarian faction but it's been a long day and the thought of diving into this topic makes me feel even more tired. 

For now, here's another reminder that, despite all the talk about the opposition to mandates and passports reflecting traditional American emphasis on freedom and individuality, previous generations were a hell of a lot less concerned with personal liberty than we are when it came to infectious diseases. 

First quarantine (1907–1910)

Soper notified the New York City Health Department, whose investigators realized that Mallon was a typhoid carrier. Under sections 1169 and 1170 of the Greater New York Charter, Mallon was arrested as a public health threat. She was forced into an ambulance by five policemen and Dr. Josephine Baker, who at some point had to sit on Mallon to restrain her. Mallon was transported to the Willard Parker Hospital, where she was restrained and forced to give samples. For four days, she was not allowed to get up and use the bathroom on her own. The massive numbers of typhoid bacteria that were discovered in her stool samples indicated that the infection center was in her gallbladder. Under questioning, Mallon admitted that she almost never washed her hands. This was not unusual at the time; the germ theory of disease still was not fully accepted.

On March 19, 1907, Mallon was sentenced to quarantine on North Brother Island. While quarantined, she gave stool and urine samples three times per week. Authorities suggested removing her gallbladder, but she refused because she did not believe she carried the disease. At the time, gallbladder removal was dangerous, and people had died from the procedure. Mallon was also unwilling to stop working as a cook, a job that earned her more money than any other. Having no home of her own, she was always on the verge of poverty.

After the publication of Soper's article in the Journal of the American Medical Association, Mallon attracted extensive media attention and received the nickname "Typhoid Mary". Later, in a textbook that defined typhoid fever, she again was called "Typhoid Mary".

Soper visited Mallon in quarantine, telling her he would write a book and give her part of the royalties. She angrily rejected his proposal and locked herself in the bathroom until he left. She hated the nickname and wrote in a letter to her lawyer:

I wonder how the said Dr. William H. Park would like to be insulted and put in the Journal and call him or his wife Typhoid William Park.

Not all medical experts supported the decision to forcibly quarantine Mallon. For example, Milton J. Rosenau and Charles V. Chapin both argued that she just had to be taught to carefully treat her condition and ensure that she would not transmit the typhoid to others. Both considered isolation to be an unnecessary, overly strict punishment. Mallon suffered from a nervous breakdown after her arrest and forcible transportation to the hospital. In 1909, she tried to sue the New York Health Department, but her complaint was denied and the case closed by the New York Supreme Court. In a letter to her lawyer, she complained that she was treated like a "guinea pig". She was obliged to give samples for analysis three times a week, but for six months was not allowed to visit an eye doctor, even though her eyelid was paralyzed and she had to bandage it at night. Her medical treatment was hectic: she was given urotropin in three-month courses for a year, threatening to destroy her kidneys. That was changed to brewers yeast and hexamethylenamin in increasing doses. She was first told that she had typhoid in her intestinal tract, then in her bowel muscles, then in her gallbladder.

Mallon herself never believed that she was a carrier. With the help of a friend, she sent several samples to an independent New York laboratory. All came back negative for typhoid. On North Brother Island, almost a quarter of her analyses from March 1907 through June 1909 were also negative. After 2 years and 11 months of Mallon's quarantine, Eugene H. Porter, the New York State Commissioner of Health, decided that disease carriers should no longer be kept in isolation and that Mallon could be freed if she agreed to stop working as a cook and take reasonable steps to avoid transmitting typhoid to others. On February 19, 1910, Mallon said she was "prepared to change her occupation (that of a cook), and would give assurance by affidavit that she would upon her release take such hygienic precautions as would protect those with whom she came in contact, from infection." She was released from quarantine and returned to the mainland.

Release and second quarantine (1915–1938)

Upon her release, Mallon was given a job as a laundress, which paid less than cooking—$20 per month instead of $50. At some point, she wounded her arm and the wound became infected, meaning that she could not work at all for six months. After several unsuccessful years, she started cooking again. She used fake surnames like Breshof or Brown, and took jobs as a cook against the explicit instructions of health authorities. No agencies that hired servants for upscale families would offer her employment, so for the next five years, she moved to the mass sector. She worked in a number of kitchens in restaurants, hotels, and spa centers. Almost everywhere she worked, there were outbreaks of typhoid. However, she changed jobs frequently, and Soper was unable to find her.

In 1915, Mallon started working at Sloane Hospital for Women in New York City. Soon 25 people were infected, and two died. The head obstetrician, Dr. Edward B. Cragin, called Soper and asked him to help in the investigation. Soper identified Mallon from the servants' verbal descriptions and also by her handwriting.

Mallon again fled, but the police were able to find and arrest her when she took food to a friend on Long Island. Mallon was returned to quarantine on North Brother Island on March 27, 1915.

Little is known about her life during the second quarantine. She remained on North Brother for more than 23 years, and the authorities gave her a private one-story cottage. As of 1918, she was allowed to take day trips to the mainland. In 1925, Dr. Alexandra Plavska came to the island for an internship. She organized a laboratory on the second floor of the chapel and offered Mallon a job as a technician. Mallon washed bottles, did recordings, and prepared glasses for pathologists.

Death

Mallon spent the rest of her life in quarantine at Riverside Hospital on North Brother Island. Mallon was quite active until suffering a stroke in 1932; afterwards, she was confined to the hospital. She never completely recovered, and half of her body remained paralyzed. On November 11, 1938, she died of pneumonia at age 69. Mallon's body was cremated, and her ashes were buried at Saint Raymond's Cemetery in the Bronx. Nine people attended the funeral