From June 19, 1909
From November 21, 1908
From February 2, 1902
Comments, observations and thoughts from two bloggers on applied statistics, higher education and epidemiology. Joseph is an associate professor. Mark is a professional statistician and former math teacher.
Very little, if anything, is known about the origin of the game. But it is known that medieval writers attributed it to Pythagoras, although no trace of it has been discovered in Greek literature, and the earliest mention of it is from the time of Hermannus Contractus (1013–1054).
The name, which appears in a variety of forms, points to a Greek origin, the more so because Greek was little known at the time when the game first appeared in literature. Based upon the Greek theory of numbers, and having a Greek name, it is still speculated by some that the origin of the game is to be sought in the Greek civilization, and perhaps in the later schools of Byzantium or Alexandria.
The first written evidence of Rithmomachia dates back to around 1030, when a monk, named Asilo, created a game that illustrated the number theory of Boëthius' De institutione arithmetica, for the students of monastery schools. The rules of the game were improved shortly thereafter by the respected monk, Hermannus Contractus, from Reichenau, and in the school of Liège. In the following centuries, Rithmomachia spread quickly through schools and monasteries in the southern parts of Germany and France. It was used mainly as a teaching aid, but, gradually, intellectuals started to play it for pleasure. In the 13th century Rithmomachia came to England, where famous mathematician Thomas Bradwardine wrote a text about it. Even Roger Bacon recommended Rithmomachia to his students, while Sir Thomas More let the inhabitants of the fictitious Utopia play it for recreation.
The game was well enough known as to justify printed treatises in Latin, French, Italian, and German, in the sixteenth century, and to have public advertisements of the sale of the board and pieces under the shadow of the old Sorbonne.
Arthur [Sackler] helped pay his medical-school tuition by taking a copywriting job at William Douglas McAdams, a small ad agency that specialized in the medical field. He proved so adept at this work that he eventually bought the agency—and revolutionized the industry. Until then, pharmaceutical companies had not availed themselves of Madison Avenue pizzazz and trickery. As both a doctor and an adman, Arthur displayed a Don Draper-style intuition for the alchemy of marketing. He recognized that selling new drugs requires a seduction of not just the patient but the doctor who writes the prescription.
Sackler saw doctors as unimpeachable stewards of public health. “I would rather place myself and my family at the judgment and mercy of a fellow-physician than that of the state,” he liked to say. So in selling new drugs he devised campaigns that appealed directly to clinicians, placing splashy ads in medical journals and distributing literature to doctors’ offices. Seeing that physicians were most heavily influenced by their own peers, he enlisted prominent ones to endorse his products, and cited scientific studies (which were often underwritten by the pharmaceutical companies themselves). John Kallir, who worked under Sackler for ten years at McAdams, recalled, “Sackler’s ads had a very serious, clinical look—a physician talking to a physician. But it was advertising.” In 1997, Arthur was posthumously inducted into the Medical Advertising Hall of Fame, and a citation praised his achievement in “bringing the full power of advertising and promotion to pharmaceutical marketing.” Allen Frances put it differently: “Most of the questionable practices that propelled the pharmaceutical industry into the scourge it is today can be attributed to Arthur Sackler.”
Advertising has always entailed some degree of persuasive license, and Arthur’s techniques were sometimes blatantly deceptive. In the nineteen-fifties, he produced an ad for a new Pfizer antibiotic, Sigmamycin: an array of doctors’ business cards, alongside the words “More and more physicians find Sigmamycin the antibiotic therapy of choice.” It was the medical equivalent of putting Mickey Mantle on a box of Wheaties. In 1959, an investigative reporter for The Saturday Review tried to contact some of the doctors whose names were on the cards. They did not exist.
During the sixties, Arthur got rich marketing the tranquillizers Librium and Valium. One Librium ad depicted a young woman carrying an armload of books, and suggested that even the quotidian anxiety a college freshman feels upon leaving home might be best handled with tranquillizers. Such students “may be afflicted by a sense of lost identity,” the copy read, adding that university life presented “a whole new world . . . of anxiety.” The ad ran in a medical journal. Sackler promoted Valium for such a wide range of uses that, in 1965, a physician writing in the journal Psychosomatics asked, “When do we not use this drug?” One campaign encouraged doctors to prescribe Valium to people with no psychiatric symptoms whatsoever: “For this kind of patient—with no demonstrable pathology—consider the usefulness of Valium.” Roche, the maker of Valium, had conducted no studies of its addictive potential. Win Gerson, who worked with Sackler at the agency, told the journalist Sam Quinones years later that the Valium campaign was a great success, in part because the drug was so effective. “It kind of made junkies of people, but that drug worked,” Gerson said. By 1973, American doctors were writing more than a hundred million tranquillizer prescriptions a year, and countless patients became hooked. The Senate held hearings on what Edward Kennedy called “a nightmare of dependence and addiction.”
A 1995 memo sent to the launch team emphasized that the company did “not want to niche” OxyContin just for cancer pain. A primary objective in Purdue’s 2002 budget plan was to “broaden” the use of OxyContin for pain management. As May put it, “What Purdue did really well was target physicians, like general practitioners, who were not pain specialists.” In its internal literature, Purdue similarly spoke of reaching patients who were “opioid naïve.” Because OxyContin was so powerful and potentially addictive, David Kessler told me, from a public-health standpoint “the goal should have been to sell the least dose of the drug to the smallest number of patients.” But this approach was at odds with the competitive imperatives of a pharmaceutical company, he continued. So Purdue set out to do exactly the opposite.
Sales reps, May told me, received training in “overcoming objections” from clinicians. If a doctor inquired about addiction, May had a talking point ready. “ ‘The delivery system is believed to reduce the abuse liability of the drug,’ ” he recited to me, with a rueful laugh. “Those were the specific words. I can still remember, all these years later.” He went on, “I found out pretty fast that it wasn’t true.” In 2002, a sales manager from the company, William Gergely, told a state investigator in Florida that Purdue executives “told us to say things like it is ‘virtually’ non-addicting.”
May didn’t ask doctors simply to take his word on OxyContin; he presented them with studies and literature provided by other physicians. Purdue had a speakers’ bureau, and it paid several thousand clinicians to attend medical conferences and deliver presentations about the merits of the drug. Doctors were offered all-expenses-paid trips to pain-management seminars in places like Boca Raton. Such spending was worth the investment: internal Purdue records indicate that doctors who attended these seminars in 1996 wrote OxyContin prescriptions more than twice as often as those who didn’t. The company advertised in medical journals, sponsored Web sites about chronic pain, and distributed a dizzying variety of OxyContin swag: fishing hats, plush toys, luggage tags. Purdue also produced promotional videos featuring satisfied patients—like a construction worker who talked about how OxyContin had eased his chronic back pain, allowing him to return to work. The videos, which also included testimonials from pain specialists, were sent to tens of thousands of doctors. The marketing of OxyContin relied on an empirical circularity: the company convinced doctors of the drug’s safety with literature that had been produced by doctors who were paid, or funded, by the company.
Constituents requesting that Rep. Jimmy Duncan Jr. (R-TN) hold a town hall on repealing the Affordable Care Act aren't being met with a polite brushoff from staffers anymore. Instead, Duncan's office has started sending out a form letter telling them point-blank that he has no intention to hold any town hall meetings.Admittedly, it is a long time until midterms, but possibly not long enough to repair this kind of damage.
“I am not going to hold town hall meetings in this atmosphere, because they would very quickly turn into shouting opportunities for extremists, kooks and radicals,” the letter read, according to a copy obtained by the Maryville Daily Times. “Also, I do not intend to give more publicity to those on the far left who have so much hatred, anger and frustration in them.”
In the first weeks of the 115th Congress, elected officials dropping by their home districts were surprised to find town halls packed to the rafters with concerned constituents. Caught off guard and on camera, lawmakers were asked to defend President Donald Trump’s immigration policies and provide a timeline on repealing and replacing the Affordable Care Act.
Now, many of them are skipping out on these events entirely. Some have said large meetings are an ineffective format for addressing individual concerns. Many others have, like the President himself, dismissed those questioning their agenda as “paid protesters” or radical activists who could pose a physical threat.
Voters turning out to town halls are pushing back hard on this characterization, arguing that they represent varied ideological backgrounds and have diverse issues to raise. Constituents unable to meet with their elected officials over the weekend told TPM that they’re not attending town hall events to make trouble. Instead, they say they want accountability from the people they pay to represent them.
Kim Mattoch, a mother of three and event planner, told TPM that she tried to go to a Saturday town hall in Roseville, California with GOP Rep. Tom McClintock but couldn’t make it in. The 200-seat theater hosting the event was quickly filled to capacity, leaving hundreds waiting outside.
“I’m a constituent of McClintock and a registered Republican in a very Republican district—though I don’t really align very well these days with the Republican Party,” Mattoch said in a Monday phone call. “So I wanted to go to the town hall because I legitimately had questions for the congressman.”
Mattoch said the protesters waiting outside had a wide range of “legitimate concerns.” She personally hoped to ask her representative about how the GOP was progressing on repealing and replacing the ACA and why House Republicans last week voted to kill a ruling aimed at preventing coal mining debris from ending up in waterways.
Yet McClintock told the Los Angeles Times that he thought an “anarchist element” was present in the crowd outside his event, and said he was escorted to his car by police because he’d been told the atmosphere was “deteriorating.”
Ramon Fliek, who attended the McClintock event with his wife, told TPM on Monday that police “were kind enough to block the whole road” to make space for the overflow crowd, and that he overheard protesters thanking law enforcement for “doing their jobs.”
“If you look at the videos from the event, you can’t get any notion that it was aggressive,” he said. “There was an older woman with a poodle that ran after him and it’s like, okay, the older lady with the poodle is not going to threaten you. I understand that he might want to give that impression, but it was very pleasant.”
For budget deficits are going to soar thanks to Republican legislation — probably by even more than the official scorekeepers say, because the legislation creates so many new loopholes. And offsetting those deficits will require going after the true big-ticket programs, namely Medicare and Social Security.
Oh, they’ll find euphemisms to describe what they’re doing, talking solemnly about the need for “entitlement reform” as an act of fiscal responsibility — while their huge budget-busting tax cut for the rich gets shoved down the memory hole. But whatever words they use to cloak the reality of the situation, Republicans have given their donors what they wanted — and now they’re coming for your benefits.I am actually a big opponent of "deficits don't matter", even when spouted by the left. I totally understand the need to invest and that low interest rates that right now is a fine time to run deficits if there is a good reason. But, in the long run, deficits either need to be paid or are going to act in an inflationary way. What is saving us, for now, is that the rich are so rich that there are a shortage of secure investment opportunities so rates are low.
Driverless cars and trucks rule the road, while robots “man” the factories. Super-smartphones hail Uber helicopters or even planes to fly their owners across mushrooming urban areas. Machines use algorithms to teach themselves cognitive tasks that once required human intelligence, wiping out millions of managerial, as well as industrial, jobs.
These are visions of a world remade — for the most part, in the next five to 10 years — by technological advances that form a fourth industrial revolution. You catch glimpses of the same visions today not only in Silicon Valley but also in Paris think tanks, Chinese electric-car factories or even here at the edge of the Sahara.
Technological disruption in the 21st century is different. Societies had years to adapt to change driven by the steam engine, electricity and the computer. Today, change is instant and ubiquitous. It arrives digitally across the globe all at once.
You'd think coming out against women's suffrage would be Thiel's low point, but he keeps exceeding expectations. https://t.co/Uvs1G0IwGV— Mark Palko (@MarkPalko1) November 23, 2017
For years I've been meaning to write something about new forms of price discrimination undermining price discovery.— Mark Palko (@MarkPalko1) November 25, 2017
Looks like I shouldn't have dragged my feet. https://t.co/TvtiaDFlT0
Interesting how these articles always say we need to develop something that sounds exactly like a CLEP without acknowledging we already have a program in place. It's almost as if focusing on making better use of existing tools isn't sexy (or profitable). https://t.co/ZFw1nEZ5Rx— Mark Palko (@MarkPalko1) November 27, 2017
Excellent work from Matt Lewis, though I'd still frame it more as "drinking from the wrong pipe."https://t.co/TmmIZhw3xB https://t.co/iJ3Xmzeple— Mark Palko (@MarkPalko1) November 28, 2017
The expression back in Arkansas was "towns that Walmart killed twice," first by opening a store that drove local merchants out of business, then by closing met store and forcing residents to drive to the next town. https://t.co/0yAgJCOuPA— Mark Palko (@MarkPalko1) December 4, 2017
As we were saying in August (point 2.2 to be precise)https://t.co/5k86uQjWOz— Mark Palko (@MarkPalko1) December 1, 2017
Republicans Are Building Themselves a Political Trap with ‘Tax Reform’ https://t.co/ChaPJSaxqb via @TPM
“Newsworthy” implies “demands coverage,” not “deserves platform.”— Mark Palko (@MarkPalko1) November 13, 2017
Under its existing model, Uber's competitive advantage is mainly based on cheap nonunion labor providing its own vehicles. Under this model, Uber has no special advantage while competitors from Amazon to Google to car rental companies to auto manufacturers are better positioned.— Mark Palko (@MarkPalko1) November 13, 2017
Josh missed the most important point, Forget racist, conspiracy theorist and fabulist. Cernovich first came to fame through the men's rights movement. Misogynists have now weaponized the backlash against harassment.— Mark Palko (@MarkPalko1) November 21, 2017
True, but those decisions were made before false balance and Clinton derangement syndrome helped put Trump in the WH. This shows the NYT has learned nothing from its mistakes. @jayrosen_nyu— Mark Palko (@MarkPalko1) November 13, 2017
Of course, if the New York Times had followed the Washington Post's lead instead of doubling down on false balance, we might not have a situation they all need to rise to.— Mark Palko (@MarkPalko1) November 20, 2017
Substitute 50s and Russian for 80s and Japanese and work in Sputnik...https://t.co/JdzsgDyDNX— Mark Palko (@MarkPalko1) November 22, 2017
An eclectic essayist is necessarily a dilettante, which is not in itself a bad thing. But Gladwell frequently holds forth about statistics and psychology, and his lack of technical grounding in these subjects can be jarring. He provides misleading definitions of “homology,” “sagittal plane” and “power law” and quotes an expert speaking about an “igon value” (that’s eigenvalue, a basic concept in linear algebra). In the spirit of Gladwell, who likes to give portentous names to his aperçus, I will call this the Igon Value Problem: when a writer’s education on a topic consists in interviewing an expert, he is apt to offer generalizations that are banal, obtuse or flat wrong.
There was just one problem, however, and it is the key to understanding the strange path that Nassim Taleb has chosen, and the position he now holds as Wall Street's principal dissident. Despite his envy and admiration, he did not want to be Victor Niederhoffer -- not then, not now, and not even for a moment in between. For when he looked around him, at the books and the tennis court and the folk art on the walls -- when he contemplated the countless millions that Niederhoffer had made over the years -- he could not escape the thought that it might all have been the result of sheer, dumb luck.
Taleb knew how heretical that thought was. Wall Street was dedicated to the principle that when it came to playing the markets there was such a thing as expertise, that skill and insight mattered in investing just as skill and insight mattered in surgery and golf and flying fighter jets.
...
For Taleb, then, the question why someone was a success in the financial marketplace was vexing. Taleb could do the arithmetic in his head. Suppose that there were ten thousand investment managers out there, which is not an outlandish number, and that every year half of them, entirely by chance, made money and half of them, entirely by chance, lost money. And suppose that every year the losers were tossed out, and the game replayed with those who remained. At the end of five years, there would be three hundred and thirteen people who had made money in every one of those years, and after ten years there would be nine people who had made money every single year in a row, all out of pure luck.
Perhaps the laws of chance should be illustrated. Let's engage in a coin flipping contest. Those who can consistently flip heads will be declared winners. The contest begins and 1,000 contestants flip coins. Just as would be expected by chance, 500 of them flip heads and these winners are allowed to advance to the second stage of the contest and flip again. As might be expected, 250 flip heads. Operating under the laws of chance, there will be 125 winners in the third round, the three in the fourth, 31 in the fifth, 16 in the sixth, and 8 in the seventh.
By this time, crowds start to gather to witness the surprising ability of these expert coin-flippers. The winners are overwhelmed with adulation. They are celebrated as geniuses in the art of coin-flipping, their biographies are written, and people urgently seek their advice. After all, there were 1000 contestants and only eight could consistently flip heads. The game continues and some contestants eventually flip heads nine and ten times in a row. [* If we had let the losers continue to play (as mutual fund managers do, even after a bad year), we would have found several more contestants who flipped eight or nine ads out of 10 and were therefore regarded as expert coin-flippers.] The point of this analogy is not to indicate that investment-fund managers can or should make their decisions by flipping coins, but that the laws of chance do operate and that they can explain some amazing success stories.
“That is the lesson of Taleb and Niederhoffer, and also the lesson of our volatile times. There is more courage and heroism in defying the human impulse, in taking the purposeful and painful steps to prepare for the unimaginable.”
The evillest place on earth. Disney's chilling response to a critical LA Times story. @jayrosen_nyu @Sulliview https://t.co/vUA6CwRtaL— Mark Palko (@MarkPalko1) November 4, 2017
Given that for years, John Tierney was the face of New York Times science writing, anything by Brad Plumer has to be a vast improvement. https://t.co/VjjfWcGKjs— Mark Palko (@MarkPalko1) November 4, 2017
Someone should do a dangers-of-concentrated-media-power on this and Disney's attack on the LA Times. @Sulliview @jayrosen_nyu https://t.co/3n5K4nCJEF— Mark Palko (@MarkPalko1) November 6, 2017
Keep in mind, YouTube is a monopoly/monopsony owned by a monopoly/monopsony with a history of abusing its power. https://t.co/WUwABkZp4h— Mark Palko (@MarkPalko1) November 6, 2017
GOP “tax reform” spin relies heavily on journalists not understanding how marginal rates work.— Mark Palko (@MarkPalko1) November 7, 2017
It is getting more and more difficult to tell whether a story came from New York Magazine or Goop. https://t.co/kAgOi2Sow3 via @strategist— Mark Palko (@MarkPalko1) November 7, 2017
Abuses of media monopoly power have been come increasingly flagrant and dangerous. Disney cannot be allowed to just walk away from this. https://t.co/82rCIScujZ— Mark Palko (@MarkPalko1) November 7, 2017
We know that at the time of the first official experiment, the two navigators of the Goubet remained eight full hours under water without any other communication with the outside world than the telephone wire that they used to give their impressions, which, by the way, were of a cheerful character. When they made their appearance, they were fresh, well, and lively, having been able to attend to all the functions of life, and being ready to begin again. There was still in the tubes enough oxygen to last twenty hours.
It has been said of the Goubet that it is a realization of the dream conceived by Jules Verne in his "Twenty Thousand Leagues under the Sea;" but the Goubet is better than that. It is not only one romance, but it is rather two of the great amuser's romances amalgamated. It is both "Twenty Thousand Leagues under the Sea" and " Doctor Ox" in action!
If you’re not following what this means, here’s an example. Suppose you’re uber-rich and you buy $1 billion in Apple Stock. By the time you die it’s worth $3 billion. Your heirs, lucky ducks that they are, don’t have to pay estate tax on that $3 billion. But they do have to pay normal capital gains on the $2 billion appreciation in the Apple stock. At 20 percent that comes to $400 million.
However, the Republican bill eliminates that too. Not only does it eliminate the estate tax completely, but it allows you to “step up” the value of the estate and avoid capital gains taxes entirely. In our example, you literally get $3 billion free and clear, and you owe taxes in the future only on the appreciation above $3 billion.Now it is possible to decide that there should not be capital gains taxes. This is actually an area of policy discussion as Canada has had a lifetime capital gains exemption. But if this is what you would like to see happen then you should do it for all capital gains and not focus all of the benefit on the wealthy. And if you don't exempt these assets from capital gains then the paperwork can get messy. So, in a sense, the estate tax is a nice way to give the gift of less paperwork to recently bereaved families (not a bad thing).
Mike Moore, the former Mississippi attorney general, believes that the Sacklers will feel no pressure to emulate this gesture until more of the public becomes aware that their fortune is derived from the opioid crisis. Moore recalled his initial settlement conference with tobacco-company C.E.O.s: “We asked them, ‘What do you want?’ And they said, ‘We want to be able to go to cocktail parties and not have people come up and ask us why we’re killing people.’ That’s an exact quote.” Moore is puzzled that museums and universities are able to continue accepting money from the Sacklers without questions or controversy. He wondered, “What would happen if some of these foundations, medical schools, and hospitals started to say, ‘How many babies have become addicted to opioids?’ ” An addicted baby is now born every half hour. In places like Huntington, West Virginia, ten per cent of newborns are dependent on opioids. A district attorney in eastern Tennessee recently filed a lawsuit against Purdue, and other companies, on behalf of “Baby Doe”—an infant addict.
The "discovery" excited international interest and many physicists worked to replicate the effects. However, the notable physicists Lord Kelvin, William Crookes, Otto Lummer, and Heinrich Rubens failed to do so. Following his own failure, self-described as "wasting a whole morning", the American physicist Robert W. Wood, who had a reputation as a popular "debunker" of nonsense during the period, was prevailed upon by the British journal Nature to travel to Blondlot's laboratory in France to investigate further. Wood suggested that Rubens should go since he had been the most embarrassed when Kaiser Wilhelm II of Germany asked him to repeat the French experiments, and then after two weeks Rubens had to report his failure to do so. Rubens, however, felt it would look better if Wood went, since Blondlot had been most polite in answering his many questions.
In the darkened room during Blondlot's demonstration, Wood surreptitiously removed an essential prism from the experimental apparatus, yet the experimenters still said that they observed N rays. Wood also stealthily swapped a large file that was supposed to be giving off N rays with an inert piece of wood, yet the N rays were still "observed". His report on these investigations were published in Nature, and they suggested that the N rays were a purely subjective phenomenon, with the scientists involved having recorded data that matched their expectations. There is reason to believe that Blondlot in particular was misled by his laboratory assistant, who confirmed all observations. By 1905, no one outside of Nancy believed in N rays, but Blondlot himself is reported to have still been convinced of their existence in 1926